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Cobalt Nanoparticles for Biomedical Applications: Facile Synthesis, Physiochemical Characterization, Cytotoxicity Behavior and Biocompatibility

作者： S.M. Ansari^a, R.D. Bhor^b, K.R. Pai^b, D. Sen^c, S. Mazumder^c, Kartik Ghosh^d, Y.D. Kolekar^a, C.V. Ramana^e

^a Department of Physics, Savitribai Phule Pune University, Pune, 411007, Maharashtra, India

^b Department of Zoology, Savitribai Phule Pune University, Pune, 411007, Maharashtra, India

^c Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai, 400 085, India

^d Department of Physics, Astronomy and Materials Science, Missouri State University, Springfield, Missouri 65897, USA

^e Department of Mechanical Engineering, University of Texas at El Paso, El Paso, Texas 79968, USA

摘要：Cobalt (Co) nanoparticles (NPs) were produced by a simple, one step hydrothermal method with the capping of oleic acid. Intrinsic structural, physiochemical and magnetic properties of Co NPs were investigated and demonstrated their applicability in biomedicine. X-ray diffraction, Raman spectroscopy and infrared (IR) spectroscopic studies confirm the single phase Co NPs with a high structural quality. The IR data revealed the capping of oleic acid via monodentate interaction. Small angle scattering studies suggest the existence of sticky hard sphere type of interaction among the Co NPs because of magnetic interaction which is further evidenced by electron microscopy imaging analyses. The Co NPs exhibit a ferromagnetic character over a wide range of temperature (20–300 K). The temperature dependence of magnetic parameters namely, saturation magnetization, remanent magnetization, coercivity and reduced remanent magnetization were determined and correlated with structure of Co NPs. The Cytotoxicity studies demonstrate that these Co NPs exhibit the mild anti-proliferative character against the cancer cells (cisplatin resistant ovarian cancer (A2780/CP70)) and safe nature towards the normal cells. Haemolytic behaviour of human red blood cells (RBC) revealed ( < 5%) haemolysis signifying the compatibility of Co NPs with human RBC which is an essential feature in vivo biomedical applications without creating any harmful effects in the human blood stream.